At age 12, De Sousa began her career doing television commercials and working as a model. In 1999, she entered the beauty pageant Miss Venezuela in the hands of the famous Venezuelan designer Giovanni Scutaro. A year later, she worked on her first telenovela, Amantes de luna llena, which was produced and broadcast by the television channel Venevisión. In 2001, she co-starred in the hit telenovela Guerra de mujeres, with the character Carolina, one of the most popular in the plot. In 2002, De Sousa left Venezuela to work on the telenovela Gata Salvaje, a co-production of Venevisión and the Spanish-American channel Univision. In this internationally acclaimed novel, she plays Camelia Valente, an antagonist in which she has perhaps been one of her best characters, achieving her international projection. At the end of that production, De Sousa went to work on the Mexican telenovela Mariana de la Noche, produced by Televisa; there her character had the name of Carol, also as an antagonist. Next, she worked on another successful Univision telenovela called Rebeca, where she had the character of Gisela, another role where she acted as an antagonist. In 2005, she starred in the telenovela Ser bonita no basta of the TV channel Radio Caracas Televisión. A year later she returned to star in another telenovela of RCTV, Y los declaro marido y mujer, a beach production set in Venezuela's Margarita Island. In 2007, De Sousa began to work in the cast of the telenovela Amor comprado, produced by Venevisión; with a character as villain of the plot called Margot. Two years later, she becomes the antagonist of the telenovela Pecadora next to Eduardo Capetillo and Litzy where she began to have skills as a singer interpreting the theme of her character and the protagonist.
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